3-O-Ethyl-L-ascorbic acid - Safety Data Sheet (2024)

Table of Contents
SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifier Relevant identified uses of the substance or mixture and uses advised against Company Identification SECTION 2: Hazards identification Classification of the substance or mixture Label elements Other hazards SECTION 3: Composition/information on ingredients Substance SECTION 4: First aid measures Description of first aid measures Most important symptoms and effects, both acute and delayed Indication of any immediate medical attention and special treatment needed SECTION 5: Firefighting measures Extinguishing media Specific Hazards Arising from the Chemical Advice for firefighters NFPA 704 SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Environmental precautions Methods and materials for containment and cleaning up SECTION 7: Handling and storage Precautions for safe handling Conditions for safe storage, including any incompatibilities SECTION 8: Exposure controls/personal protection Control parameters Exposure controls Individual protection measures SECTION 9: Physical and chemical properties Information on basic physicochemical properties SECTION 10: Stability and reactivity Reactivity Chemical stability Possibility of hazardous reactions Conditions to avoid Incompatible materials Hazardous decomposition products SECTION 11: Toxicological information Acute toxicity Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard SECTION 12: Ecological information Toxicity Persistence and degradability Bioaccumulative potential Mobility in soil Other adverse effects SECTION 13: Disposal considerations Disposal methods SECTION 14: Transport information UN Number UN Proper Shipping Name Transport hazard class(es) Packing group, if applicable Environmental hazards Special precautions for user Transport in bulk according to IMO instruments SECTION 15: Regulatory information Safety, health and environmental regulations specific for the product in question SECTION 16: Other information Abbreviations and acronyms References FAQs

Chemical Safety Data Sheet MSDS / SDS

Revision Date:2024-08-10Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 3-O-Ethyl-L-ascorbic acid
  • CBnumber: CB8511566
  • CAS: 86404-04-8
  • EINECS Number: 617-849-3
  • Synonyms: ETHYL ASCORBIC ACID,3-O-Ethyl-L-ascorbic acid

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company: Chemicalbook
  • Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
  • Telephone: 400-158-6606

SECTION 2: Hazards identification

Classification of the substance or mixture

Eye irritation, Category 2

Label elements

Pictogram(s)

3-O-Ethyl-L-ascorbic acid - Safety Data Sheet (1)

  • Signal word

    Warning

Hazard statement(s)

H319 Causes serious eye irritation

Precautionary statement(s)

Prevention

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

Response

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Storage

none

Disposal

none

Other hazards

no data available

SECTION 3: Composition/information on ingredients

Substance

  • Product name: 3-O-Ethyl-L-ascorbic acid
  • Synonyms: ETHYL ASCORBIC ACID,3-O-Ethyl-L-ascorbic acid
  • CAS: 86404-04-8
  • EC number: 617-849-3
  • MF: C8H12O6
  • MW: 204.18

SECTION 4: First aid measures

Description of first aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Most important symptoms and effects, both acute and delayed

no data available

Indication of any immediate medical attention and special treatment needed

no data available

SECTION 5: Firefighting measures

Extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

NFPA 704

2

HEALTH 2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
FIRE 0 Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride)
REACT 0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

Exposure controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

  • Physical stateSolid
  • ColourWhite to Off-White
  • Odour

    no data available

  • Melting point/freezing point

    115 °C. Atm. press.:1 013 hPa.

  • Boiling point or initial boiling point and boiling range

    Remarks:Reaction and/or decomposition of the test item was observed starting at 250 °C. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.

  • Flammability

    no data available

  • Lower and upper explosion limit/flammability limit

    no data available

  • Flash point

    14°C(lit.)

  • Auto-ignition temperature

    no data available

  • Decomposition temperature

    no data available

  • pH

    no data available

  • Kinematic viscosity

    no data available

  • SolubilityMethanol (Slightly), Water (Slightly)
  • Partition coefficient n-octanol/water

    log Pow = -0.8. Temperature:20 °C.

  • Vapour pressure

    <= 0 Pa. Temperature:20 °C.;<= 0 Pa. Temperature:25 °C.

  • Density and/or relative density

    1.47 g/cm3. Temperature:20 °C.

  • Relative vapour density

    no data available

  • Particle characteristics

    no data available

SECTION 10: Stability and reactivity

Reactivity

no data available

Chemical stability

no data available

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

no data available

Hazardous decomposition products

no data available

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 - >= 13 - <= 10 000 microG. Remarks:Results based on many compounds.
  • Inhalation: no data available
  • Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

SECTION 12: Ecological information

Toxicity

  • Toxicity to fish: no data available
  • Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 78 mg/L - 48 h.
  • Toxicity to algae: EC50 - Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) - > 81 mg/L - 72 h.
  • Toxicity to microorganisms: no data available

Persistence and degradability

no data available

Bioaccumulative potential

no data available

Mobility in soil

no data available

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Transport hazard class(es)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Packing group, if applicable

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)

Not Listed.

EC Inventory

Not Listed.

United States Toxic Substances Control Act (TSCA) Inventory

Not Listed.

China Catalog of Hazardous chemicals 2015

Not Listed.

New Zealand Inventory of Chemicals (NZIoC)

Not Listed.

PICCS

Not Listed.

Vietnam National Chemical Inventory

Not Listed.

IECSC

Not Listed.

Korea Existing Chemicals List (KECL)

Not Listed.

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

3-O-Ethyl-L-ascorbic acid - Safety Data Sheet (2024)

FAQs

Is 3 0 ethyl ascorbic acid safe to use? ›

It is a semi-synthetic substance that is characterised by higher bioavailability, stability, solubility, and non-toxicity, as compared to its natural counterpart. This makes it a safe and stable product that can be used for a myriad of different applications, including in skincare products.

What is the difference between ethyl ascorbic acid and 3 O ethyl ascorbic acid? ›

Ethyl Ascorbic Acid is also known as 3-O-Ethyl-L-ascorbic Acid. It is a molecule formed by modifying Ascorbic Acid or, as we know it better, vitamin C. So why is the modification done? Well, to make the compound more stable, of course.

What is 3-O-ethyl-L-ascorbic acid? ›

3-O-ethyl-l-ascorbic acid (EA) is an l-ascorbic acid derivative with an ethyl group at the third carbon position. This structural modification protects the 3-OH group from ionization, and thus the molecule from oxidation, but also results in changes in the physicochemical properties.

What is the health hazard data of L ascorbic acid? ›

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes and respiratory tract. Ingestion of large amounts may cause gastrointestinal distress and diarrhea. Exposure may also cause the formation of renal calcium oxalate calculi.

What percentage of ethyl ascorbic acid is effective? ›

Usage levels of 3-O ethyl ascorbic acid in skin care typically fall between 0.5–5%. Due to its stability, lesser amounts are needed compared with pure vitamin C. Levels above 5% may also be used, depending on desired benefits. Amounts up to 30% have been shown to be non-irritating on human skin samples.

Is 3-O ethyl ascorbic acid anti aging? ›

3-O ethyl ascorbic acid is a stable, water- and oil-soluble derivative of pure vitamin C (ascorbic acid) that offers all of the primary benefits vitamin C is known for, such as brightening, wrinkle reduction, visible firming, fading hyperpigmentation to restore a more even skin tone and offsetting numerous triggers of ...

What are the disadvantages of ethyl ascorbic acid? ›

The anti-inflammatory properties of Vitamin C help to soothe the irritated skin. Hence, it has become the key ingredient in many skincare products. The only drawback of this magical beauty ingredient is that it is highly unstable and easily oxidizes when exposed to light and air, thereby reducing its efficiency.

What is ethyl ascorbic acid ethyl ascorbic acid? ›

Ethyl Ascorbic Acid or EAC for short is an "etherified derivative of ascorbic acid" that consists of vitamin C and an ethyl group bound to the third carbon position. This makes Vitamin C very stable and soluble in both water and oil.

Can 3-O-ethyl ascorbic acid be used with niacinamide? ›

Here's the good news: Yes, you can use products that contain vitamin C with products that contain niacinamide in your skin care routine.

What is the difference between ascorbic and L-ascorbic? ›

The name “L-ascorbic” refers to the chemical structure of the type of vitamin C and how it reacts to light. You may have heard of ascorbic acid — the form of vitamin C used in dietary supplements taken orally. But L-ascorbic is given its name based on how it rotates when exposed to light.

How long is ethyl ascorbic acid stable for? ›

For better stability and to avoid pH-drift to acidic pH- values the use of 1 % citrate buffer is recommended. Ethyl Ascorbic Acid is stable for more than 90 days under different conditions (45°C, -15°C, room tem- perature and under day light).

Which form of vitamin C is best for skin? ›

It is important to remember that while derivatives of vitamin C can be absorbed into the skin, they will not always convert into active vitamin C, therefore products that include L-ascorbic acid (pure vitamin C for skin) are preferable.

What is the danger of ascorbic acid? ›

Adverse effects include headaches, flushing, nausea or vomiting, and dizziness (IV use). There are reports of migraine headaches with a daily dose of 6 g. Significant amounts of vitamin C can increase the risk of kidney stones and elevate uric acid and oxalate because it acidifies the urine.

What are the safety precautions for ascorbic acid? ›

Use chemical gloves as needed. Use clean protective body covering clothing as needed to minimize contact with clothing and skin. Handle in accordance with good industrial hygiene and safety practice. Wash and dry hands at the end of workday.

How much ascorbic acid is safe? ›

The upper limit for all adults is 2,000 mg a day. Although too much dietary vitamin C is unlikely to be harmful, large doses of vitamin C supplements might cause: Diarrhea. Nausea.

What not to mix with ethyl ascorbic acid? ›

Vitamin C is effectively an acid (it's sometimes known as ascorbic acid), so layering it with AHAs and BHAs like glycolic, salicylic, and lactic acids is a big no-no.

When should you not use ascorbic acid? ›

If you are pregnant, talk to your doctor before taking more than 1,000 mg of vitamin C. People with sickle cell anemia, as well as people with a metabolic disorder called G6PD, can potentially have serious side-effects from taking high levels of vitamin C.

What percentage of ascorbic acid is best? ›

Concentration: The sweet spot for the concentration level is between 10 and 20 percent. You definitely want a concentration that's higher than 8 percent for maximum effectiveness. But going over 20 percent could lead to irritation and doesn't increase its benefit.

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